Multi-Inflammatory Syndrome in Children (MIS-C)
DisasterFact Sheet: Multisystem Inflammatory Syndrome in Children (MIS-C)
Developed by the Rhode Island Department of Health. Click here to access the document.
Boston Children’s Hospital COVID-19 Treatment: Internal Guidance
This guidance was developed by a multi-specialty team of Boston Children’s Hospital (BCH) clinicians to assist with evaluating and treating patients who present to BCH seeking care related to symptoms or complications of coronavirus disease 2019 (COVID-19), including Multisystem Inflammatory Syndrome in Children (MIS-C). Click here to access the guidelines.
COVID-19 in Kids – It’s Not a Small Problem
June 9, 2020
The purpose of this JEMS report is to provide EMS professionals with situational awareness of COVID-19 illness in pediatric patients. Click here to read the report.

How to spot symptoms of MIS-C, a rare condition in children exposed to COVID-19
This infographic from the Michigan Department of Health and Human Services summarizes the signs of MIS-C.

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19)
May 14, 2020
The CDC Health Alert Network released a document characterizing the history and presentation of the syndrome. Click here to ready the alert: https://emergency.cdc.gov/han/2020/han00432.asp
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19)
CDC Clinician Outreach and Communication Activity (COCA) Webinar
May 19, 2020

Infographic: Multisystem Inflammatory Syndrome in Children
Developed by the Maryland Institute for Emergency Medical Services Systems
May 21, 2020
Click Here to Download: http://www.miemss.org/home/Portals/0/Docs/Infectious_Diseases/Guidance-COVID-19-Multisystem-Inflammatory-Syndrome-20200522.pdf?ver=2020-05-22-112548-013
COVID-19 New Syndrome in Children
Dr. John Campbell | May 14, 2020
Recommended Links

CDC details COVID-19-related inflammatory syndrome in children
May 14, 2020; AAP News
Childhood Inflammatory Disease Related to COVID-19
NYC Department of Health. MIS-C Case Tracking Dashboard
Emergency Department, ICU and Inpatient Clinical Pathway for Evaluation of Possible Multisystem Inflammatory Syndrome (MIS-C)
Children's Hospital of Philadelphia
May 2020
Webinar: Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus 2019 (COVID-19)
New York State Department of Health
May 21, 2020
Multisystem inflammatory syndrome in children and COVID-19
Brad Sobolewski, PEM Blog. May 15th, 2020
Rapid risk assessment: Paediatric inflammatory multisystem syndrome and SARS -CoV-2 infection in children
European Centre for Disease Prevention and Control
May 15, 2020
From the Literature
Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic
Zahra Belhadjer, MD, et al. Circulation. June 1, 2020
Paediatric Inflammatory Multi-system Syndrome – temporally associated with SARS-CoV 2 (PIMS-TS): Critical Care guidance
Pediatric Intensive Care Society. May 14, 2020.
Case Report Form for suspected cases of multisystem inflammatory syndrome (MIS) in children and adolescents temporally related to COVID-19
World Health Organization (WHO). Global COVID-19 Clinical Platform
June 1, 2020
Kawasaki-like Inflammatory Disease Affects Children With COVID-19
Diagnostic and Interventional Cardiology. May 20, 2020
COVID-19: Overview and Evaluation – Pediatric Collection
American Academy of Pediatrics-FREE ACCESS
Experts shed more light on COVID-19-related inflammatory syndrome in children
AAP News. Melissa Jenco, News Content Editor
May 20, 2020
COVID-19 and Kawasaki Disease: Finding the Signal in the Noise
Alan R. Schroeder, MD; Karen M Wilson, MD MPH; Shawn L. Ralston, MD Hospital Pediatrics. May 2020 DOI: 10.1542/hpeds.2020-000356
Multisystem inflammatory syndrome in children and adolescents with COVID-19 -Scientific Brief
World Health Organization. May 15, 2020
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19)
May 14, 2020; CDC Health Alert Network
An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study
Lucio Verdoni, MD, Angelo Mazza, MD, Annalisa Gervasoni, MD, et al. The Lancet. May 13, 2020. DOI:https://doi.org/10.1016/S0140-6736(20)31103-X
Mitigating the Impacts of the COVID-19 Pandemic Response on At-Risk Children
Charlene A. Wong, David Ming, Gary Maslow and Elizabeth J. Gifford. Pediatrics April 2020, e20200973; DOI: https://doi.org/10.1542/peds.2020-0973
COVID-19 and Kawasaki Disease: Novel Virus and Novel Case
Jones VG, Mills M, Suarez D, et al. COVID-19 and Kawasaki disease: novel virus and novel case. Hosp Pediatr. April 2020; doi: 10.1542/hpeds.2020-0123
COVID-19 and Multi-System Inflammatory Syndrome in Children
May 15, 2020; healthychildren.org
- Coronavirus (COVID-19)
- Multi-Inflammatory Syndrome in Children (MIS-C)
- Hospital Pediatric Preparedness
- Prehospital Providers (EMS & Pediatricians)
- Family & Caregiver Preparedness
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- State EMSC Resources
- PPE, Calculators & Essential Skills
- Infographics and Presentations
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- Mental & Behavioral Health