Ohio — Targeted Issue

Diagnostic Signatures in Febrile Infants

July 1, 2009 - Feb. 29, 2012

Grant Number
Project Overview
Infants with fever commonly present to the ED. Most febrile infants have non-bacterial infections, but 6-10% have severe bacterial infections. Current diganostic methods are not precise. We propose studying a new method to improve the diagnosis of febrile infants in the PECARN network. The goals of this project are to (1) educate and train a core group of PECARN investigators to conduct research in RNA microarray transcriptional technologies in febrile infants; (2) demonstrate the ability of the PECARN network to obtain high-quality RNA samples used for microarray analysis from febrile infants across multiple participating PECARN EDs; and (3) define the initial diagnostic bacterial biosignatures using RNA microarray transcriptional technologies in young febrile infants presenting to the ED.

(grant moved from University of Texas Southwestern after year 2)
Nationwide Children's Hospital
Main Contacts
Award Amount


Name Role(s) Phone Email
Prashant Mahajan
  • Co-Principal Investigator
Octavio Ramilo, MD
  • Principal Investigator


Title Format Description Published/Revised Availability
Application of Transcriptional Signatures for Diagnosis of Febrile Infants within the PECARN Network Podcast 2012 Not Available


Title Type Publication/Event Published/Presented Identifier Details
Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections Research Paper/Publication JAMA Pediatrics 2018
Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger Research Paper/Publication Pediatrics 2018
Epidemiology of Bacteremia in Febrile Infants Aged 60 Days and Younger Research Paper/Publication Annals of Emergency Medicine 2018
The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants Research Paper/Publication Pediatrics 2017