Texas — Targeted Issue
Diagnostic Signatures in Febrile Infants
Sept. 1, 2007 - June 30, 2009
- Project Overview
- Infants with fever commonly present to the ED. Most febrile infants have non-bacterial infections, but 6-10% have severe bacterial infections. Current diganostic methods are not precise. We propose studying a new method to improve the diagnosis of febrile infants in the PECARN network.
Goals: (1) educate and train a core group of PECARN investigators to conduct research in RNA microarray transcriptional technologies in febrile infants; (2) demonstrate the ability of the PECARN network to obtain high-quality RNA samples used for microarray analysis from febrile infants across multiple participating PECARN EDs; and (3) define the initial diagnostic bacterial biosignatures using RNA microarray transcriptional technologies in young febrile infants presenting to the ED.
(moved to Nationwide Children's Hospital after year 2)
- University of Texas Southwestern Medical Center
- Main Contact
- Award Amount
|Octavio Ramilo, MD||
|Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections||Research Paper/Publication||JAMA Pediatrics||
|Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger||Research Paper/Publication||Pediatrics||
|Epidemiology of Bacteremia in Febrile Infants Aged 60 Days and Younger||Research Paper/Publication||Annals of Emergency Medicine||
|The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants||Research Paper/Publication||Pediatrics||