Ohio — Targeted Issue
Diagnostic Signatures in Febrile Infants
July 1, 2009 - Feb. 29, 2012

Details

Institution
Nationwide Children's Hospital (moved from UT Southwestern Medical Center at Dallas in Texas)
Principal Investigator(s)
Award Amount
$294366.00
Follow Up
Application of Transcriptional Signatures for Diagnosis of Febrile Infants within the PECARN Network

Regions

HRSA Region

5

EMSC Region

CARE

HPP Region

5

NASEMSO Region

Great Lakes

Contacts

Name Roles Agency Mailing Address Office Phone Email
Octavio Ramilo/Prashant Mahajan,
  • Principal Investigator
Nationwide Children's Hospital (moved from UT Southwestern Medical Center at Dallas in Texas)

Products

Title Published Description Format Availability
Application of Transcriptional Signatures for Diagnosis of Febrile Infants within the PECARN Network: 2012 Audiocast Not Available

Disseminations

Title Published Author Abstract Publication PMID
Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia. 2012 Aquino VM, Cost C, Gomez A, Bowers DC, Ramilo O, Ahmad N, Winick N, Leavey PJ A variety of clinical and laboratory parameters have been used to predict bacteremia. This study hypothesized that the generation of a cytokine profile could be used to identify patients at higher risk of bacteremia at the time of presentation with febrile neutropenia. We prospectively evaluated children with cancer who presented with an episode of febrile neutropenia. A multiplexed flow cytometric assay was performed which measured 15 cytokines and chemokines obtained before the initiation of antibiotics. Fifty-eight episodes of chemotherapy-induced febrile neutropenia were included in this study during which 4 patients (7%) had bacteremia. An interleukin-5 level of >8 pg/dL had a sensitivity of 67% and a specificity of 96% to predict bacteremia. An monocyte chemotactic protein-1 level >1650 pg/dL had a sensitivity of 80% and a specificity of 82% to predict bacteremia. Erythrocyte sedimentation rate, C-reactive protein, protein C, and other cytokines/chemokines were not predictive of bacteremia. Elevations of interleukin-5 and monocyte chemotactic protein-1 are predictive of bacteremia in children with cancer who have febrile neutropenia. Prospective studies should be undertaken to determine whether these parameters retain predictive value in a larger series of patients and can select children for outpatient management or early discharge. J Pediatr Hematol Oncol. 22584776